A randomized, placebo-controlled trial of lubiprostone for opioid-induced constipation in chronic noncancer pain.

Am J Gastroenterol · 2015 · PMC4424379 · PMID 25916220

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did not reach statistical significanceno p-value reported

Numerical differences favoring lubiprostone were observed between the treatment groups for abdominal bloating and abdominal discomfort; however, the differences did not reach statistical significance.

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