Trabecular numbers showed a trend of reduction in the KK-Ay diabetic mice compared with the control group ( Figure 4 b); however, trabecular separation was significantly increased in KK-Ay diabetic mice compared with the controls ( p < 0.05) ( Figure 4 d).
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High insulin levels in KK-Ay diabetic mice cause increased cortical bone mass and impaired trabecular micro-structure.
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