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The in-vivo use of superparamagnetic iron oxide nanoparticles to detect inflammation elicits a cytokine response but does not aggravate experimental arthritis.

PLoS One · 2015 · PMC4425489 · PMID 25955417

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showed a trendno p-value reported
Acute phase protein gene expression of Saa1 showed a trend toward upregulation.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.