In vivo structure-function studies of human hepatic lipase: the catalytic function rescues the lean phenotype of HL-deficient (hl-/-) mice.

Cumulative food intake over the entire period of HFD feeding was increased by 10% in female hl −/− mice-expressing active HL compared with those expressing the ciHL mutant ( P = 0.02), and a similar trend was observed in male hl −/− mice rescued with intact human HL ( hl −/− hHL ) compared to those expressing ciHL, although the difference did not reach statistical significance (Table 3 ).

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