showed a trendP < 0.05
Similarly, the area under the curve (AUC) of the 3 mg/kg or 10 mg/kg ciclamilast-treated and the 0.1 mg/kg MTX-treated groups also showed a trend toward less paw edema compared with the vehicle-treated rats (each P < 0.05 or 0.01) ( Figure 1 ). 3.2.