Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.

6g,h ), the neurons from FD subjects showed a trend toward decrease in number ( Fig. 6i ; 16.5 ± 1.1 HC neurons/well, n=60 wells; 14.1 ± 1.1 FD neurons/well, n=60 wells; difference between HC neurons/well and FD neurons/well 2.3 ± 1.5, n=60 wells; random intercept mixed-effects model p=0.26) and a robust reduction in neurite outgrowth per cell ( Fig

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