Hypoxic culture of bone marrow-derived mesenchymal stromal stem cells differentially enhances in vitro chondrogenesis within cell-seeded collagen and hyaluronic acid porous scaffolds.

Stem Cell Res Ther · 2015 · PMC4431536 · PMID 25900045

Europe PMC DOI

hedged sentences

0.0900

closest p · 1.8× alpha

0.0900

boldest claim

The sentences

approached significanceP = 0.09so close (0.05 < p ≤ 0.1)

HA scaffolds seeded with BMSCs and differentiated under hypoxia had significantly higher mRNA expressions of aggrecan and collagen II ( P <0.05; Figure 4 G and H) and an increased collagen II/I ratio that approached significance ( P = 0.09).

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highly significantno p-value reported

Although this finding was demonstrated previously in human BMSC pellets [ 14 ], others have reported highly significant findings following hypoxic differentiation in human BMSC pellet [ 19 ] and porcine BMSC pellet and hydrogel [ 15 ] models.

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