While combination therapy consistently resulted in the greatest attenuation of glomerular damage as well as suppression of autoantibody production and lymphoproliferation, the observed differences between ganetespib monotherapy and combination treatment did not reach statistical significance in a study of this size.
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The HSP90 Inhibitor Ganetespib Alleviates Disease Progression and Augments Intermittent Cyclophosphamide Therapy in the MRL/lpr Mouse Model of Systemic Lupus Erythematosus.
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