Identification of Disease-Promoting HLA Class I and Protective Class II Modifiers in Japanese Patients with Familial Mediterranean Fever.

Among 42 estimations, only OR of B*52 : 01 adjusted for DRB1*15 : 02 and that of DRB1*15 : 02 adjusted for B*52 : 01 were profoundly attenuated by adjustment, because B*52 : 01 and DRB1*15 : 02 were associated non-randomly as one of ancestral HLA haplotypes in the Japanese population.[ 11 ] Although it did not reach statistical significance, a point estimation of OR of DRB1*15 : 02 remained less than one regardless of the presence or absence of B*52 : 01 , but not in vice versa ( Table 4 ), suggesting the primary role of DRB1*15 : 02 in the protective effect conferred by the B*52 : 01 - DRB1*15 : 02 haplotype.

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