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Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer's disease: a voxel-based lesion mapping study.

Alzheimers Res Ther · 2015 · PMC4432954 · PMID 25984242

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showed a trendno p-value reported
Mechanisms of tissue damage Carriers of the ε4 allele exhibited lower WMH volume than non-carriers, but they also showed a trend toward more prominent hippocampal atrophy, which is an early focus of AD pathology [ 56 ].

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