Impaired Th17 polarization of phenotypically naive CD4(+) T-cells during chronic HIV-1 infection and potential restoration with early ART.

Despite donor-to-donor variations in the dynamic of these three subsets before and after ART, in all 4/4 donors the initiation of ART led to a modest marginally significant increase in the counts of nTregs, DP cells, mTh17 cells (Figure 7 C).

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In addition, there was a tendency for superior Gag HIV-DNA levels in DP versus nT cells from the 5/5 subjects, but results did not reach statistical significance (Figure 5 D).

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