In the present study, mice that had undergone chronic restraint stress showed a trend towards decreased phosphorylation of mTOR and its downstream effector P70S6K in the PFC, though the effect was not statistically significant compared with unstressed mice ( Figure 3a ).
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The mood stabilizer lithium potentiates the antidepressant-like effects and ameliorates oxidative stress induced by acute ketamine in a mouse model of stress.
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