The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells.

Compared to mice treated only with vehicle (water), mice treated with harmine exhibited a statistically significant increase (∼20%) in the frequency of T reg cells in the draining thoracic lymph nodes; increases in absolute numbers of effector T cell subsets did not reach statistical significance ( Figure 2F and Figure 2—figure supplement 1 ).

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