We further assessed the association of LIN28A and LIN28B expression with survival in stage I–III CRC and found that high expression of LIN28A was significantly associated with worse CRC-specific survival, while the association of high LIN28B expression did not reach statistical significance ( Fig. 5 F,G).
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LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans.
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