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The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells.

BMC Cancer · 2015 · PMC4445981 · PMID 25981639

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While these effects did not reach statistical significance, DL-TBOA also tended to increase pRb levels under control conditions in both parental cell lines, and slightly but consistently decreased pRb levels after oxaliplatin treatment in all cell types except oxaliplatin-resistant HCT116 cells.

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