Statin-Induced Increases in Atrophy Gene Expression Occur Independently of Changes in PGC1α Protein and Mitochondrial Content.

As shown in Fig 6 , simvastatin induced a significant decrease in -HAD activity in the EDL Sim 60 and Sim 80 groups ( Fig 6C ), with a strong trend (p = 0.05, main effect) for a decrease in the PLT Sim 60 and Sim 80 groups ( Fig 6B ).

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