Progesterone and Src family inhibitor PP1 synergistically inhibit cell migration and invasion of human basal phenotype breast cancer cells.

Using a wound closure assay, we found that the wound closure (WC) of MB231Br cells was slower (even though only marginally significant) when the cells were treated with P4 (30 ng/mL) for 16 hrs as compared to the cells without P4 treatment (40.6 ± 2.7% versus 50.0 ± 0.6%, MIR 18.9%, P WC = 0.06, Figure 3 ).

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