Associations of Haplotypes Upstream of IRS1 with Insulin Resistance, Type 2 Diabetes, Dyslipidemia, Preclinical Atherosclerosis, and Skeletal Muscle LOC646736 mRNA Levels.

In comparison to the most common haplotype 1112, fasting insulin levels and HOMA-IR values of haplotypes 1221 and 2221 were significantly higher and lower, respectively ( Table 1 ), and the difference between 1221 and 2221 was highly significant ( P = 0.00006).

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Comparison of genotype frequencies between 600 type 2 diabetes patients and 1350 glucose tolerant SAPHIR participants revealed nominally significant effects of rs7578326, rs2943634, and rs2943641 as well as a borderline effect of rs2713538 (Supplementary Table 13).

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