A negative trend in PFS over time is reported because data decline from 5.5 months of the TARGET study ( Escudier et al , 2007a ) to 4.7 months of the AXIS trial ( Rini et al , 2011 ) and finally to the 3.9 months of the last trial INTORSECT ( Hutson et al , 2013a ).
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Comparing comparators: a look at control arms in kidney cancer studies over the years.
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