Key role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells.

In all three cell lines tested, TTK knockdown by the three independent siRNAs led to a significant reduction in proliferation rates compared with cells treated with non-silencing control siRNA ( Figure 2B ), with the exception of si3 in Panc1 cells, where the proliferation was also lower but did not reach statistical significance.

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These results were confirmed in MTT assays, where knockdown of TTK expression with any of the three independent siRNAs in any of the three pancreatic cancer cell lines led to statistically highly significant decrease in the viability of the cells as compared with controls ( Figure 2C ).

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