Comparing the percentage reduction of non-diabetic versus STZ-diabetic HDAd-LDLR treated mice revealed a significant impairment of the regression of CD68+ cells in STZ-diabetic mice; in non-diabetic mice CD68+ cells decreased by 77% versus a 57% decrease in STZ-diabetic mice (p<0.01) The percentage difference in plaque size regression between non-diabetic and STZ-diabetic mice also showed a trend to decrease less in the latter (36% vs. 51%, respectively).
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Effects of High Fat Feeding and Diabetes on Regression of Atherosclerosis Induced by Low-Density Lipoprotein Receptor Gene Therapy in LDL Receptor-Deficient Mice.
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