29 However, the effect by febuxostat in left ventricular ejection fraction did not reach statistical significance despite previously reported improvement in ejection fraction by oxypurinol. 29 Although little is known about the consequences of wasting on cardiac function 30 and whether it leads to heart failure or impaired survival, some of the drugs used in heart failure treatment would be effective in our previous study. 16 As febuxostat was also reported to be effective in mouse and dog models of heart failure, 21 , 24 the survival effect in the present study could be influenced by the effect on the heart to some extent.
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