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Do patterns of mental healthcare predict treatment failure in young people with schizophrenia? Evidence from an Italian population-based cohort study.

BMJ Open · 2015 · PMC4458586 · PMID 26041489

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In our application, we extended the use of the rule-out approach in the situations where the observed association did not reach statistical significance, and the interest was to detect the extension of confounding required to make statistically significant the exposure–outcome association.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.