Powerful Tukey's One Degree-of-Freedom Test for Detecting Gene-Gene and Gene-Environment Interactions.

Cancer Inform · 2015 · PMC4459566 · PMID 26064040

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hedged sentences

0.0020

closest p · 0.0× alpha

0.1000

boldest claim

The sentences

highly significantP -value = 0.002actually significant

Of note, one of the 19 SNPs was the top hit in the GWAS of pancreatic cancer 40 (rs505922 in gene ABO ), and its interaction with smoking on the risk of pancreatic cancer was highly significant ( P -value = 0.002 by SNP × smoking test based on Model (2) and P -value = 0.038 after the Bonferroni correction).

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nominally significantP -values <0.1so close (0.05 < p ≤ 0.1)

Twelve nominally significant genes that had P -values <0.1 were tested for pairwise G × G interactions, as in Ref. 12 .

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