Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome.

Moreover, although there was a trend towards reduction in the number of IFNγ-producing DLN cells, specifically CD4 + , CD8 + and γδ T cells following PMA/Ionomycin stimulation, this did not reach statistical significance ( Fig. 1 J and results not shown).

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