Mice injected with scAAV9-Syn-Nudt7 or scAAV9-Syn-Nudt7cyt showed a similar reduction in motor coordination at 9 weeks of age; however, mice with neuronal overexpression of Nudt7cyt exhibited a strong trend towards a reduced performance also at 17 weeks of age.
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Induction of Neuron-Specific Degradation of Coenzyme A Models Pantothenate Kinase-Associated Neurodegeneration by Reducing Motor Coordination in Mice.
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