Lack of a Functioning P2X7 Receptor Leads to Increased Susceptibility to Toxoplasmic Ileitis.

However, the loss -of-function Arg-307-Glu polymorphism of P2X7R is associated with IBD, albeit the association is borderline significant (p = 0.06) from a relatively small number of cases and unaccompanied by any association between IBD and other loss- or gain-of-function polymorphisms [ 25 ].

also in 11,409 other papers

However, uninfected P2X7R -/- mice possessed higher baseline levels of phosphorylated NFκB ( Fig 4B ), phosphorylated p38 MAPK ( Fig 4C ), and lower levels of the negative regulator, phosphorylated CREB ( Fig 4D ) than uninfected C57BL/6J, although these results did not reach statistical significance.

also in 111,027 other papers