Inhibition of hypoxia inducible factors combined with all-trans retinoic acid treatment enhances glial transdifferentiation of neuroblastoma cells.

1 , high mRNA levels of HIF1A were significantly associated with lower overall survival and relapse-free survival in both sets of patients, whereas high expression levels of EPAS1 showed significant association with lower overall survival and a trend toward an association with lower relapse-free survival, although this did not reach statistical significance.

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