The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response.

Transl Psychiatry · 2015 · PMC4462610 · PMID 25897834

Europe PMC DOI

hedged sentences

0.0100

closest p · 0.2× alpha

0.0610

boldest claim

The sentences

nominally significantP =0.010actually significant

Nominally significant association was also found for SNP rs7174755 in ITGA11 (integrin, alpha 11) in the combined ISPC+AMPS sample ( P =0.010 for association with %ΔHRSD; P =0.025 for response).

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marginally significantP =0.061so close (0.05 < p ≤ 0.1)

12 , 13 Although the observed associations are not significant after correction for multiple testing of SNPs selected for these replication analyses, we observed marginally significant evidence of association of SNP rs11624702 in MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2) with response in the ISPC alone ( P =0.061) and in the combined ISPC-AMPS-STAR*D meta-analysis ( P =0.029), with the minor allele being associated with lower odds of response (that is, worse clinical outcomes).

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