Comprehensive behavioral analysis of voltage-gated calcium channel beta-anchoring and -regulatory protein knockout mice.

, Science and Technology (MEXT) of Japan Institute for Comprehensive Medical Science Fujita Health University (Joint Usage/Research Center for Genes, Brain and Behavior accredited by MEXT) in Japan Decreased locomotor activity in BARP KO mice In the light/dark transition test, BARP KO mice showed a nominally significant decrease in total distance traveled in the light and dark chambers, and number of transitions compared with WT mice [genotype effect, F (1, 42) = 4.945, p = 0.0316; genotype × time effect, F (1, 42) = 0.100, p = 0.7536 and t = 2.939, df = 42, p = 0.0053, respectively] (Figures 2A,C ).

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A Two-Way repeated measures ANOVA showed no significant genotype effect, while there was marginally significant interaction in time around cage [genotype effect, F (1, 42) = 1.425, p = 0.2393; genotype × side interaction, F (1, 42) = 3.790, p = 0.0583].

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In the context and cued tests 1 day after conditioning, BARP KO mice also showed decreased freezing, though differences in the suppression ratio failed to reach significance between BARP KO and WT mice during the context test and during cue presentation in the cued test, possibly due to the lower levels of basal freezing in BARP KO mice.

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