Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidence.

Compared with controls, WT/H5LO mice had an increase in GSAP-16 kDa fragment levels, which did not reach statistical significance, whereas no significant differences were observed between the two groups for GSAP-FL, TMP21 and CD147 steady state levels ( Fig. 5g,h ).

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