25 Following this narrowing, the list of differentially expressed genes due to knockdown of CHD8 contained a total of 27 overlapping genes excluding CHD8 ( Table 2 ), which did not reach statistical significance for enrichment ( P =0.153, OR=1.378).
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The autism-associated gene chromodomain helicase DNA-binding protein 8 (CHD8) regulates noncoding RNAs and autism-related genes.
2
0.1530
0.1530
The sentences
De novo loss-of-function mutations were identified in 12 individuals with ASD and zero controls, accounting for a highly significant association.