Immunogens Modeling a Fusion-Intermediate Conformation of gp41 Elicit Antibodies to the Membrane Proximal External Region of the HIV Envelope Glycoprotein.

Like the prior study, we noted that the groups that received the DNA priming vectors with one of the gp41 constructs gave better MPER responses than the groups that received the gp160 DNA priming vector ( Table 3 , prime-boost study #3, groups N3-1and N3-2 compared to group N3-3, groups N3-4, and N3-5 compared to N3-6, and groups N3-7 and N-38 compared to N3-9), but the differences failed to reach statistical significance.

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