Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk.

PLoS One · 2015 · PMC4474865 · PMID 26091520

Europe PMC DOI

hedged sentences

0.0200

closest p · 0.4× alpha

0.0503

boldest claim

The sentences

modestly significantP = 0.02actually significant

Previously, the UGT1A7*3 allele exhibited modestly significant association with colorectal cancer (OR = 2.39; P = 0.02) [ 57 ], lung cancer [ 62 ], endometrial cancer [ 63 ] and pancreatic cancer (OR = 1.98; P = 0.003) [ 64 ] with a particularly strong association in smokers with pancreatic carcinoma who were younger than 55 years (OR = 4.7; P = 0.0009), suggesting the magnitude of the observed associations may be modified by environmental interactions.

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of borderline significanceP = 0.042actually significant

This SNP was of borderline significance in women of white-European (OR = 0.95; P = 0.042), but not Asian (P>0.05), ancestry.

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nominally significantp<0.05actually significant

Among the 279 cellular transport SNPs genotyped in the replication set, 81 SNPs in 48 genes showed nominally significant (p<0.05) associations with at least one histological subtype ( S2 Table ).

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borderline significantP = 0.0503so close (0.05 < p ≤ 0.1)

SERPINA7 rs1804495 was borderline significant (P = 0.0503), perhaps due to a small sample size.

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