Association between AKT1 Gene Polymorphism rs2498794 and Smoking-Related Traits with reference to Cancer Susceptibility.

Interestingly, this SNP had a marginally significant association with individual cancer history (past and current), especially in groups with a shorter smoking duration (<44 years) and fewer cigarettes per day (≤20).

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To explore the associations between the SNPs and phenotypes related to smoking and cancer in the initial 300 subjects, the χ 2 test was performed overall, and SNPs that showed P < 0.05 in the analysis were considered nominally significant and selected for further analysis.

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