Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism.

Overexpression of irs2 and btr01 protects against acute hypoxic stress in the absence of preconditioning During MO knockdown and rescue experiments, we noted that btr01 morphants injected with rescue btr01 mRNA showed a trend toward lower lethality when subjected to sH in the absence of hPC ( Figure 5B ).

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