We detected nominally significant heterogeneity (p = 0.048) among the data sets in the rs6500843 analysis, indicating some disagreement between data sets; the SNP-associated increased hazard was not seen in the SUCCESS-A data set.
In an enrichment analysis for Gene Ontology biological processes, using an arbitrary raw eQTL p-value threshold of p < 10 −5 to select an expanded candidate gene list, GO terms involved in cell cycle control, mitosis and DNA replication emerged as highly significant for the trans-eQTLs (34 probes representing 28 genes) in the rs6500843 locus (Table 3 ).