Clinical Translation and Validation of a Predictive Biomarker for Patritumab, an Anti-human Epidermal Growth Factor Receptor 3 (HER3) Monoclonal Antibody, in Patients With Advanced Non-small Cell Lung Cancer.

Internal validation was provided through exploratory analyses, which showed that decreasing ∆Ct values (i.e., increasing HRG mRNA expression levels) showed a trend for improved clinical benefit (i.e., lower HR) for patients treated with patritumab plus erlotinib compared with placebo plus erlotinib.

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