The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes.

Transfection of SKOV3 cells with the truncated variant of PPARa led to the further significant reduction of cell viability while the effect on MCF7 cells was also consistent over time, yet did not reach statistical significance (Fig. 7b , bottom panel).Of note, the cell viability curves generated for SKOV3 cells overexpressing either PPARα-wt or PPARα-tr cDNA in the presence of two additional PPARα ligands, clofibrate and GW7647, confirmed that the observed effects are not due to a ligand dependent effect on different splice variants (Additional file 4 : Figure S3).

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