An increase was seen in the uptake of 100 nm U-PS particles by the addition of SP-A to AMs isolated from both groups of mice, but this did not reach statistical significance (WT: p = 0.26 and SP-A −/− : p = 0.17; Figure 5C ).
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Surfactant protein A (SP-A) inhibits agglomeration and macrophage uptake of toxic amine modified nanoparticles.
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