Nevertheless, the reduction of the MVD in HF-treated mice did not reach statistical significance (158 ± 32.5 vs. 118 ± 35 microvessels/mm 2 in controls ( n = 5) and treated leukemic mice ( n = 5), respectively).
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Halofuginone inhibits phosphorylation of SMAD-2 reducing angiogenesis and leukemia burden in an acute promyelocytic leukemia mouse model.
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