Mediation by inflammation did not reach statistical significance in either sex.
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Sex-Specific Mediating Role of Insulin Resistance and Inflammation in the Effect of Adiposity on Blood Pressure of Prepubertal Children.
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In girls, we found that the association of WHtR with SBP was mainly explained by a significant direct effect (74.1%) and an indirect effect mediated by IR (20.5%), whereas the effect of hsCRP was only borderline significant ( Table 4 ).
In the younger group, hsCRP was not significantly related to either adiposity measures or BP, whereas highly significant correlations between hsCRP and adiposity measures as well as BP were evident in the older group which, as in our study, were attenuated when adjusted for covariates [ 41 ].