Drug Metabolizing Enzyme and Transporter Gene Variation, Nicotine Metabolism, Prospective Abstinence, and Cigarette Consumption.

After analyses by mode of administration, we observed increased abstinence at end-of-treatment and at six months, with a trend towards significance ( p -values < .10) in individuals randomized to NRT patch [in 339 individuals, OR end-of-treatment (95%CI) P = 1.348 (0.961–1.890) 0.084 and OR six months (95%CI) P = 1.386 (0.973–1.975) 0.071].

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Nominally significant associations were identified in ten genes after adjustment for intragenic SNPs; CYP2A6 and two CYP2A6 SNPs attained experiment-wide significance adjusted for correlated SNPs ( CYP2A6 P ACT =4.1E-7, rs4803381 P ACT =4.5E-5, rs1137115, P ACT =1.2E-3).

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