Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells.

p110β inactivation also led to reduced expression of other SC-specific AR targets in adult testes, including TJP1 (Tight Junction Protein 1) and claudin11 (a transmembrane protein important for tight junctions), although the reduction in the expression of claudin11 did not reach statistical significance ( Fig 5A , right panel ).

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