Correlation between arthroscopic infusion volumes and perioperative morphine requirements did not reach statistical significance; this result may be explained by the confounding effects of the routinely co-administered analgesics (intra-articular local anaesthetic and opioid, non-steroidal anti-inflammatory and tramadol) as well as the common observation that in situations of intense postoperative pain and escalating opioid dosing, early signs of sedation and respiratory depression contraindicate further opioid administration even though patient reported NRS scores may remain elevated.
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