Treatment of Prion Disease with Heterologous Prion Proteins.

Decreases in high-dose treated verses mock-treated mice were most pronounced and highly significant in the thalamus ( p = 0.000557 by a 2 sample t -test); no significant differences in staining were seen amongst groups in the hippocampus ( p = 0.825 for the high-dose group compared to the mock treated group and p = 0.839 for the low-dose group compared to the mock treated group, again with a 2 sample t -test).

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The high-dose-treated mice showed a trend of less GFAP accumulation in the brain compared to mock-treated mice ( p = 0.103 by a 2 sample t -test on the logarithms of the levels), whereas no difference was detected between the low-dose-treated and mock infected mice ( p = 0.906 again by a 2 sample t -test) as seen in Fig 2 .

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