DJ-1 links muscle ROS production with metabolic reprogramming and systemic energy homeostasis in mice.

Nat Commun · 2015 · PMC4490365 · PMID 26077864

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DJ-1 deficiency also conferred metabolic protection in a genetic model of obesity such that Dj1 −/− Lep ob/ob mice showed a trend towards reduced body weight and were more glucose tolerant compared with Dj1 +/+ Lep ob/ob littermates ( Supplementary Fig. 7f,g ).

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