The most significantly associated SNP from CYP2R1 had a consistent direction of association with FEV 1 in the meta-analyzed set of replication cohorts, but the association did not reach statistical significance thresholds ( P = 0.09).
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Association of 25-Hydroxyvitamin D status and genetic variation in the vitamin D metabolic pathway with FEV1 in the Framingham Heart Study.
1
0.0900
0.0900