Inhaled Pharmacotherapy and Stroke Risk in Patients with Chronic Obstructive Pulmonary Disease: A Nationwide Population Based Study Using Two-Stage Approach.

PLoS One · 2015 · PMC4497597 · PMID 26158649

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did not reach statistical significancep < 0.001actually significant

However, after two-stage propensity score calibration ( Table 4 ), the impact of SAMA on stroke risk did not reach statistical significance, while the adjusted HR for stroke was increased to 1.67 (95% CI 1.45–1.91, p < 0.001) with the use of SABA.

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