Environmental enrichment reverses histone methylation changes in the aged hippocampus and restores age-related memory deficits.

Using Western blotting analysis, we observed a strong trend towards elevation, but non-significant increase in baseline resting H3K9me2 ( Figure 1 A; t (9) = 1.863, p = 0.0954) and a significant increase in H3K4me3 levels ( Figure 1 A; t (17) = 2.881, p = 0.0104) in area CA1 of the hippocampus from aged adults compared to young adults.

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